Inhibition of STAT3 signaling as critical molecular event in resveratrol-suppressed ovarian cancer cells
نویسندگان
چکیده
منابع مشابه
Inhibition of STAT3 signaling as critical molecular event in resveratrol-suppressed ovarian cancer cells
BACKGROUND Resveratrol exerts inhibitory effects on ovarian cancer cells, while its underlying mechanism and critical molecular target(s) have been lesser known. Activations of Wnt, Notch and STAT3 signaling are frequent in ovarian cancers/OCs and supposed to be important for OC formation and progression, while the impacts of resveratrol on these signaling pathways in OC cells remain obscure. ...
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In this study, the potential influence of resveratrol (3,5,4'-trihydroxy-trans-stilbene) in signal transducer and activator of transcription 3 (STAT3) signaling of medulloblastoma cells was evaluated by checking the status of STAT3 signaling and its downstream gene expression in two medulloblastoma cell lines (UW228-2 and UW228-3) with and without resveratrol treatment. The results revealed tha...
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BACKGROUND Activated STAT3 signaling is critical for human medulloblastoma cells. SHP2, SOCS3 and PIAS3 are known as the negative regulators of STAT3 signaling, while their relevance to frequent STAT3 activation in medulloblastomas remains unknown. METHODS Tissue microarrays were constructed with 17 tumor-surrounding noncancerous brain tissues and 61 cases of the classic medulloblastomas, 44 ...
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ژورنال
عنوان ژورنال: Journal of Ovarian Research
سال: 2015
ISSN: 1757-2215
DOI: 10.1186/s13048-015-0152-4